Karin Borges Selected Research

triheptanoin

6/2020	Open-label long-term treatment of add-on triheptanoin in adults with drug-resistant epilepsy.
1/2020	Triheptanoin alters [U-13C6]-glucose incorporation into glycolytic intermediates and increases TCA cycling by normalizing the activities of pyruvate dehydrogenase and oxoglutarate dehydrogenase in a chronic epilepsy mouse model.
3/2019	Randomized trial of add-on triheptanoin vs medium chain triglycerides in adults with refractory epilepsy.
11/2018	A pilot study of add-on oral triheptanoin treatment for children with medically refractory epilepsy.
1/2018	Heptanoate is neuroprotective in vitro but triheptanoin post-treatment did not protect against middle cerebral artery occlusion in rats.
1/2018	Triheptanoin protects against status epilepticus-induced hippocampal mitochondrial dysfunctions, oxidative stress and neuronal degeneration.
2/2016	Modification of Astrocyte Metabolism as an Approach to the Treatment of Epilepsy: Triheptanoin and Acetyl-L-Carnitine.
1/2016	Triheptanoin Protects Motor Neurons and Delays the Onset of Motor Symptoms in a Mouse Model of Amyotrophic Lateral Sclerosis.
4/2014	Triheptanoin partially restores levels of tricarboxylic acid cycle intermediates in the mouse pilocarpine model of epilepsy.
1/2013	Triheptanoin reduces seizure susceptibility in a syndrome-specific mouse model of generalized epilepsy.

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Karin Borges Research Topics

Disease

24	Epilepsy (Aura) 01/2022 - 07/2003
19	Seizures (Absence Seizure) 01/2022 - 07/2003
16	Status Epilepticus (Complex Partial Status Epilepticus) 01/2022 - 07/2003
6	Drug Resistant Epilepsy 06/2020 - 01/2011
5	Inflammation (Inflammations) 01/2017 - 10/2008
4	Nervous System Diseases (Neurological Disorders) 01/2021 - 01/2014
4	Body Weight (Weight, Body) 03/2019 - 12/2010
3	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2021 - 01/2016
2	Mitochondrial Diseases (Mitochondrial Disease) 01/2018 - 01/2016
2	Temporal Lobe Epilepsy 07/2013 - 07/2003
1	Cancer Pain 10/2022
1	Disease Progression 01/2021
1	Autism Spectrum Disorder 01/2020
1	Mental Disorders (Mental Disorder) 01/2020
1	Spasm (Spasms) 10/2018
1	Infantile Spasms (West Syndrome) 10/2018
1	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 01/2018
1	Stroke (Strokes) 01/2018
1	Hyperglycemia 01/2017
1	Muscle Weakness 01/2016
1	Paralysis (Palsy) 01/2016
1	Alzheimer Disease (Alzheimer's Disease) 01/2014
1	Hypoglycemia (Reactive Hypoglycemia) 01/2013
1	Generalized Epilepsy 01/2013
1	Metabolic Diseases (Metabolic Disease) 05/2012
1	Myoclonic Epilepsies (Myoclonic Encephalopathy) 11/2011
1	Generalized Epilepsy with Febrile Seizures Plus 11/2011
1	Ketosis 10/2008
1	Glioma (Gliomas) 09/2003
1	Hippocampal Sclerosis 07/2003

Drug/Important Bio-Agent (IBA)

19	Pilocarpine (Ocusert)FDA LinkGeneric 01/2022 - 07/2003
14	Glucose (Dextrose)FDA LinkGeneric 01/2021 - 11/2011
13	triheptanoinIBA 06/2020 - 12/2010
10	Anticonvulsants (Antiepileptic Drugs)IBA 01/2021 - 10/2008
7	Triglycerides (Triacylglycerol)IBA 01/2021 - 05/2012
6	Flurothyl (Flurotyl)IBA 01/2018 - 10/2008
4	Oxidoreductases (Dehydrogenase)IBA 01/2020 - 01/2017
4	Pyruvic Acid (Pyruvate)IBA 01/2020 - 01/2017
4	Pentylenetetrazole (Metrazol)IBA 02/2016 - 10/2008
2	GlycogenIBA 01/2022 - 01/2017
2	Fatty Acids (Saturated Fatty Acids)IBA 01/2021 - 01/2021
2	octanoic acid (caprylic acid)IBA 01/2021 - 03/2019
2	decanoic acid (capric acid)IBA 01/2021 - 01/2021
2	Complement System Proteins (Complement)IBA 10/2018 - 04/2015
2	Neuroprotective AgentsIBA 01/2018 - 04/2007
2	CholesterolIBA 01/2017 - 10/2016
2	sulforaphaneIBA 01/2017 - 12/2015
2	Messenger RNA (mRNA)IBA 06/2015 - 08/2013
2	Kainic Acid (Kainate)IBA 06/2015 - 04/2015
1	Analgesics (Analgesic Drugs)IBA 10/2022
1	Ketamine FDA LinkGeneric 10/2022
1	Glutamate-Ammonia Ligase (Glutamine Synthetase)IBA 01/2022
1	Saline SolutionIBA 01/2021
1	fructose-1,6-diphosphate (fructose 1,6-diphosphate)IBA 01/2021
1	Ketone BodiesIBA 01/2021
1	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2020
1	Ketoglutarate Dehydrogenase Complex (Oxoglutarate Dehydrogenase)IBA 01/2020
1	Biomarkers (Surrogate Marker)IBA 11/2018
1	Adrenocorticotropic Hormone (ACTH)FDA Link 10/2018
1	Proteins (Proteins, Gene)FDA Link 01/2018
1	Tricarboxylic AcidsIBA 06/2017
1	Lactic Acid (Lactate)FDA LinkGeneric 01/2017
1	PhosphofructokinasesIBA 01/2017
1	Alanine (L-Alanine)FDA Link 01/2017
1	QuercetinIBA 10/2016
1	Acetylcarnitine (Alcar)IBA 02/2016
1	Pharmaceutical PreparationsIBA 02/2016
1	Adenosine Triphosphate (ATP)IBA 01/2016
1	Glial Fibrillary Acidic ProteinIBA 06/2015
1	Complement Receptors (Complement Receptor)IBA 04/2015
1	Anaphylatoxin C5a ReceptorIBA 04/2015
1	Amino Acids FDA Link 07/2013
1	Glutamic Acid (Glutamate)FDA Link 07/2013
1	gamma-Aminobutyric Acid (GABA)IBA 01/2013
1	Blood Glucose (Blood Sugar)IBA 01/2013
1	Insulin (Novolin)FDA Link 01/2013
1	3-Hydroxybutyric Acid (beta-Hydroxybutyric Acid)IBA 01/2011
1	OsteopontinIBA 10/2008
1	Phenytoin (Dilantin)FDA LinkGeneric 05/2007
1	polycaprolactoneIBA 05/2007
1	GAP-43 Protein (GAP 43 Protein)IBA 07/2004
1	Neuropeptide YIBA 07/2004
1	LuciferasesIBA 09/2003

Therapy/Procedure

2	Injections 01/2021 - 12/2015
2	Ketogenic Diet 11/2011 - 01/2011
1	Glycemic Control 10/2016
1	Denervation 01/2016
1	Therapeutics 01/2013